| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZP3 (246-345) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZP3 |
| Gene ID: |
7784 |
| Uniprot ID: |
ZP3_HUMAN |
| Immunogen Region: |
246-345 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 246-345 of human ZP3 (NP_001103824.1). |
| Immunogen Sequence: |
DASSAFKVPRPGPDTLQFTV DVFHFANDSRNMIYITCHLK VTLAEQDPDELNKACSFSKP SNSWFPVEGSADICQCCNKG DCGTPSHSRRQPHVMSQWSR |
| Tissue Specificity | Expressed in oocytes (at protein level). |
| Post Translational Modifications | Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida. N-glycosylated. O-glycosylated.removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy. |
| Function | Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. |
| Protein Name | Zona Pellucida Sperm-Binding Protein 3Sperm ReceptorZp3a/Zp3bZona Pellucida Glycoprotein 3Zp-3Zona Pellucida Protein C Cleaved Into - Processed Zona Pellucida Sperm-Binding Protein 3 |
| Database Links | Reactome: R-HSA-2534343 |
| Cellular Localisation | Processed Zona Pellucida Sperm-Binding Protein 3: Zona PellucidaCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Zona Pellucida Sperm-Binding Protein 3 antibodyAnti-Sperm Receptor antibodyAnti-Zp3a/Zp3b antibodyAnti-Zona Pellucida Glycoprotein 3 antibodyAnti-Zp-3 antibodyAnti-Zona Pellucida Protein C Cleaved Into - Processed Zona Pellucida Sperm-Binding Protein 3 antibodyAnti-ZP3 antibodyAnti-ZP3A antibodyAnti-ZP3B antibodyAnti-ZPC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
