| Tissue Specificity | Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes. |
| Function | Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. |
| Protein Name | Zinc Finger Fyve Domain-Containing Protein 9Mothers Against Decapentaplegic Homolog-Interacting ProteinMadh-Interacting ProteinNovel Serine ProteaseNspReceptor Activation AnchorHsaraSmad Anchor For Receptor Activation |
| Database Links | Reactome: R-HSA-2173788 O95405-1Reactome: R-HSA-2173789 O95405-1Reactome: R-HSA-3304356 O95405-1Reactome: R-HSA-3656532 O95405-1 |
| Cellular Localisation | CytoplasmEarly Endosome Membrane |
| Alternative Antibody Names | Anti-Zinc Finger Fyve Domain-Containing Protein 9 antibodyAnti-Mothers Against Decapentaplegic Homolog-Interacting Protein antibodyAnti-Madh-Interacting Protein antibodyAnti-Novel Serine Protease antibodyAnti-Nsp antibodyAnti-Receptor Activation Anchor antibodyAnti-Hsara antibodyAnti-Smad Anchor For Receptor Activation antibodyAnti-ZFYVE9 antibodyAnti-MADHIP antibodyAnti-SARA antibodyAnti-SMADIP antibody |
Information sourced from Uniprot.org
