| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZEB2 |
| Gene ID: | 9839 |
| Uniprot ID: | ZEB2_HUMAN |
| Immunogen Region: | 1050-1214 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1050-1214 of human ZEB2 (NP_055610.1). |
| Immunogen Sequence: | SGEKPYQCDKCGKRFSHSGS YSQHMNHRYSYCKREAEERE AAEREAREKGHLEPTELLMN RAYLQSITPQGYSDSEERES MPRDGESEKEHEKEGEDGYG KLGRQDGDEEFEEEEEESEN KSMDTDPETIRDEEETGDHS MDDSSEDGKMETKSDHEEDN MEDGM |
| Post Translational Modifications | Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity. |
| Function | Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. Represses expression of MEOX2. |
| Protein Name | Zinc Finger E-Box-Binding Homeobox 2Smad-Interacting Protein 1Smadip1Zinc Finger Homeobox Protein 1b |
| Database Links | Reactome: R-HSA-9762293Reactome: R-HSA-9823739Reactome: R-HSA-9832991 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Zinc Finger E-Box-Binding Homeobox 2 antibodyAnti-Smad-Interacting Protein 1 antibodyAnti-Smadip1 antibodyAnti-Zinc Finger Homeobox Protein 1b antibodyAnti-ZEB2 antibodyAnti-KIAA0569 antibodyAnti-SIP1 antibodyAnti-ZFHX1B antibodyAnti-ZFX1B antibodyAnti-HRIHFB2411 antibody |
Information sourced from Uniprot.org