| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZCWPW1 |
| Gene ID: | 55063 |
| Uniprot ID: | ZCPW1_HUMAN |
| Immunogen Region: | 389-648 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 389-648 of human ZCWPW1 (NP_060454.3). |
| Immunogen Sequence: | VMKKRRNDCSQKLGVALMMA QEAEQISIQERVNLFGFWSR FNGSNSNGERKDLQLSGLNS PGSCLEKKEKEEELEKEEGE KTDPILPIRKRVKIQTQKTK PRGLGGDAGTADGRGRTLQR KIMKRSLGRKSTAPPAPRMG RKEGQGNSDSDQPGPKKKFK APQSKALAASFSEGKEVRTV PKNLGLSACKGACPSSAKEE PRHREPLTQEAGSVPLEDEA SSDLDLEQLMEDVGRELGQ |
| Tissue Specificity | Testis. |
| Function | Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3). Facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs). Essential for male fertility and spermatogenesis. Required for meiosis prophase I progression in male but not in female germ cells. |
| Protein Name | Zinc Finger Cw-Type Pwwp Domain Protein 1 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Zinc Finger Cw-Type Pwwp Domain Protein 1 antibodyAnti-ZCWPW1 antibody |
Information sourced from Uniprot.org
