| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZC3HC1 |
| Gene ID: |
51530 |
| Uniprot ID: |
ZC3C1_HUMAN |
| Immunogen Region: |
1-260 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ZC3HC1 (NP_057562.3). |
| Immunogen Sequence: |
MAAPCEGQAFAVGVEKNWGA VVRSPEGTPQKIRQLIDEGI APEEGGVDAKDTSATSQSVN GSPQAEQPSLESTSKEAFFS RVETFSSLKWAGKPFELSPL VCAKYGWVTVECDMLKCSSC QAFLCASLQPAFDFDRYKQR CAELKKALCTAHEKFCFWPD SPSPDRFGMLPLDEPAILVS EFLDRFQSLCHLDLQLPSLR PEDLKTMCLTEDKISLLLHL LEDELDHRTDERKTTIKLG |
| Tissue Specificity | Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes. |
| Post Translational Modifications | Phosphorylated. May also be weakly phosphorylated on Tyr residues. |
| Function | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. |
| Protein Name | Zinc Finger C3hc-Type Protein 1Nuclear-Interacting Partner Of AlkHnipaNuclear-Interacting Partner Of Anaplastic Lymphoma Kinase |
| Database Links | Reactome: R-HSA-9725371 |
| Cellular Localisation | NucleusNucleus EnvelopeResident Of The Nuclear Basket (Nb)Occurs At The Nuclear Envelopes (Ne) Of All Tpr-Containing Cell TypesIncluding Proliferating And Non-DividingTerminally Differentiated Cells Of Different Morphogenetic Origin |
| Alternative Antibody Names | Anti-Zinc Finger C3hc-Type Protein 1 antibodyAnti-Nuclear-Interacting Partner Of Alk antibodyAnti-Hnipa antibodyAnti-Nuclear-Interacting Partner Of Anaplastic Lymphoma Kinase antibodyAnti-ZC3HC1 antibodyAnti-NIPA antibodyAnti-HSPC216 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and APEH knockout (KO) 293T cells, using [KO Validated] APEH Rabbit polyclonal antibody (STJ11100788) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89724/358205/STJ11100788_1__51624.1713122526.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and APEH knockout (KO) 293T cells, using [KO Validated] APEH Rabbit polyclonal antibody (STJ11100788) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")