| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZC3HC1 |
| Gene ID: | 51530 |
| Uniprot ID: | ZC3C1_HUMAN |
| Immunogen Region: | 1-260 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ZC3HC1 (NP_057562.3). |
| Immunogen Sequence: | MAAPCEGQAFAVGVEKNWGA VVRSPEGTPQKIRQLIDEGI APEEGGVDAKDTSATSQSVN GSPQAEQPSLESTSKEAFFS RVETFSSLKWAGKPFELSPL VCAKYGWVTVECDMLKCSSC QAFLCASLQPAFDFDRYKQR CAELKKALCTAHEKFCFWPD SPSPDRFGMLPLDEPAILVS EFLDRFQSLCHLDLQLPSLR PEDLKTMCLTEDKISLLLHL LEDELDHRTDERKTTIKLG |
| Tissue Specificity | Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes. |
| Post Translational Modifications | Phosphorylated. May also be weakly phosphorylated on Tyr residues. |
| Function | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. |
| Protein Name | Zinc Finger C3hc-Type Protein 1 Nuclear-Interacting Partner Of Alk Hnipa Nuclear-Interacting Partner Of Anaplastic Lymphoma Kinase |
| Database Links | Reactome: R-HSA-9725371 |
| Cellular Localisation | Nucleus Nucleus Envelope Resident Of The Nuclear Basket (Nb) Occurs At The Nuclear Envelopes (Ne) Of All Tpr-Containing Cell Types Including Proliferating And Non-Dividing Terminally Differentiated Cells Of Different Morphogenetic Origin |
| Alternative Antibody Names | Anti-Zinc Finger C3hc-Type Protein 1 antibody Anti-Nuclear-Interacting Partner Of Alk antibody Anti-Hnipa antibody Anti-Nuclear-Interacting Partner Of Anaplastic Lymphoma Kinase antibody Anti-ZC3HC1 antibody Anti-NIPA antibody Anti-HSPC216 antibody |
Information sourced from Uniprot.org