| Function | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). |
| Protein Name | Zinc Finger Ccch-Type Antiviral Protein 1Adp-Ribosyltransferase Diphtheria Toxin-Like 13Artd13Inactive Poly Adp-Ribose Polymerase 13Parp13Zinc Finger Ccch Domain-Containing Protein 2Zinc Finger Antiviral ProteinZap |
| Database Links | Reactome: R-HSA-6802952 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusLocalizes In The Cytoplasm At Steady StateBut Shuttles Between Nucleus And Cytoplasm In A Xpo1-Dependent MannerIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Zinc Finger Ccch-Type Antiviral Protein 1 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 13 antibodyAnti-Artd13 antibodyAnti-Inactive Poly Adp-Ribose Polymerase 13 antibodyAnti-Parp13 antibodyAnti-Zinc Finger Ccch Domain-Containing Protein 2 antibodyAnti-Zinc Finger Antiviral Protein antibodyAnti-Zap antibodyAnti-ZC3HAV1 antibodyAnti-ZC3HDC2 antibodyAnti-PRO1677 antibody |
Information sourced from Uniprot.org
