| Tissue Specificity | Detected in adrenal gland and neuroblastoma. |
| Function | Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A. Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression. In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs. |
| Protein Name | Zinc Finger And Btb Domain-Containing Protein 48Krueppel-Related Zinc Finger Protein 3Hkr3Telomere Zinc Finger-Associated ProteinTzapTelomere-Binding Protein And Transcriptional Activator Zbtb48Zinc Finger Protein 855 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeTelomereDirectly Binds The Telomeric Double-Stranded 5'-Ttaggg-3' RepeatAccording To A ReportPreferentially Binds To Long Telomeres That Have A Low Concentration Of Shelterin ComplexCompeting With The Telomeric Repeat Binding Factors Terf1 And Terf2According To Another ReportBinds Telomeres Regardless Of Their Length |
| Alternative Antibody Names | Anti-Zinc Finger And Btb Domain-Containing Protein 48 antibodyAnti-Krueppel-Related Zinc Finger Protein 3 antibodyAnti-Hkr3 antibodyAnti-Telomere Zinc Finger-Associated Protein antibodyAnti-Tzap antibodyAnti-Telomere-Binding Protein And Transcriptional Activator Zbtb48 antibodyAnti-Zinc Finger Protein 855 antibodyAnti-ZBTB48 antibodyAnti-HKR3 antibodyAnti-TZAP antibodyAnti-ZNF855 antibody |
Information sourced from Uniprot.org
