| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZBTB17 |
| Gene ID: | 7709 |
| Uniprot ID: | ZBT17_HUMAN |
| Immunogen Region: | 121-360 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 121-360 of human ZBTB17 (NP_003434.2). |
| Immunogen Sequence: | PGGNAEALATEGGDKRAKEE KVATSTLSRLEQAGRSTPIG PSRDLKEERGGQAQSAASGA EQTEKADAPREPPPVELKPD PTSGMAAAEAEAALSESSEQ EMEVEPARKGEEEQKEQEEQ EEEGAGPAEVKEEGSQLENG EAPEENENEESAGTDSGQEL GSEARGLRSGTYGDRTESKA YGSVIHKCEDCGKEFTHTGN FKRHIRIHTGEKPFSCRECS KAFSDPAACKAHEKTHSPL |
| Tissue Specificity | Expressed in germinal center B-cells. |
| Post Translational Modifications | Undergoes 'Lys-48'-linked polyubiquitination at Lys-397 and Lys-481 and subsequent proteasomal degradation in a TRAF2-dependent manner. |
| Function | Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription.this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1. |
| Protein Name | Zinc Finger And Btb Domain-Containing Protein 17 Myc-Interacting Zinc Finger Protein 1 Miz-1 Zinc Finger Protein 151 Zinc Finger Protein 60 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger And Btb Domain-Containing Protein 17 antibody Anti-Myc-Interacting Zinc Finger Protein 1 antibody Anti-Miz-1 antibody Anti-Zinc Finger Protein 151 antibody Anti-Zinc Finger Protein 60 antibody Anti-ZBTB17 antibody Anti-MIZ1 antibody Anti-ZNF151 antibody Anti-ZNF60 antibody |
Information sourced from Uniprot.org