| Host: | Rabbit |
| Applications: | WB/IHC/IP/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-14-3-3 protein zeta/delta (24-73 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunoprecipitation, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IP 2-5 ug mg/lysate IF 1:200-1:1000 ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | YWHAZ |
| Gene ID: | 7534 |
| Uniprot ID: | 1433Z_HUMAN |
| Immunogen Region: | 24-73 aa |
| Specificity: | 14-3-3 Zeta Polyclonal Antibody detects endogenous levels of 14-3-3 Zeta protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human 14-3-3 zeta at the amino acid range 24-73 |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity. |
| Protein Name | 14-3-3 Protein Zeta/Delta Protein Kinase C Inhibitor Protein 1 Kcip-1 |
| Database Links | Reactome: R-HSA-111447 Reactome: R-HSA-1445148 Reactome: R-HSA-3769402 Reactome: R-HSA-392517 Reactome: R-HSA-430116 Reactome: R-HSA-450604 Reactome: R-HSA-512988 Reactome: R-HSA-5625740 Reactome: R-HSA-5628897 Reactome: R-HSA-75035 Reactome: R-HSA-9013700 Reactome: R-HSA-9604323 Reactome: R-HSA-9614399 Reactome: R-HSA-9735871 Reactome: R-HSA-9755779 |
| Cellular Localisation | Cytoplasm Melanosome Located To Stage I To Stage Iv Melanosomes |
| Alternative Antibody Names | Anti-14-3-3 Protein Zeta/Delta antibody Anti-Protein Kinase C Inhibitor Protein 1 antibody Anti-Kcip-1 antibody Anti-YWHAZ antibody |
Information sourced from Uniprot.org