| Short Description : | Rabbit polyclonal YWHAH (1-246) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | YWHAH |
| Gene ID: | 7533 |
| Uniprot ID: | 1433F_HUMAN |
| Immunogen Region: | 1-246 |
| Immunogen Sequence: | MGDREQLLQRARLAEQAERY DDMASAMKAVTELNEPLSNE DRNLLSVAYKNVVGARRSSW RVISSIEQKTMADGNEKKLE KVKAYREKIEKELETVCNDV LSLLDKFLIKNCNDFQYESK VFYLKMKGDYYRYLAEVASG EKKNSVVEASEAAYKEAFEI SKEQMQPTHPIRLGLALNFS VFYYEIQNAPEQACLLAKQA FDDAIAELDTLNEDSYKDST LIMQLLRDNLTLWTSDQQD |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-246 of human YWHAH (NP_003396.1). |
| Tissue Specificity | Expressed mainly in the brain and present in other tissues albeit at lower levels. |
| Post Translational Modifications | Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. |
| Protein Name | 14-3-3 Protein EtaProtein As1 |
| Database Links | Reactome: R-HSA-111447Reactome: R-HSA-1445148Reactome: R-HSA-5625740Reactome: R-HSA-5628897Reactome: R-HSA-75035Reactome: R-HSA-9735871Reactome: R-HSA-9755779Reactome: R-HSA-9856649 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-14-3-3 Protein Eta antibodyAnti-Protein As1 antibodyAnti-YWHAH antibodyAnti-YWHA1 antibody |
Information sourced from Uniprot.org
