| Tissue Specificity | Present in male and female germ cells (at protein level). Highly expressed in testis. Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis (at protein level). |
| Function | 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis. |
| Protein Name | 3'-5' Rna Helicase Ythdc2Keen To Exit Meiosis Leaving Testes Under-Populated ProteinKetuYth Domain-Containing Protein C2Mythdc2 |
| Database Links | |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-3'-5' Rna Helicase Ythdc2 antibodyAnti-Keen To Exit Meiosis Leaving Testes Under-Populated Protein antibodyAnti-Ketu antibodyAnti-Yth Domain-Containing Protein C2 antibodyAnti-Mythdc2 antibodyAnti-Ythdc2 antibody |
Information sourced from Uniprot.org
![Immunoprecipitation of YTHDC2 in 200 µg extracts from 293T cells using 0. 5 µg [KD Validated] YTHDC2 Rabbit polyclonal antibody (STJ11105298). Western blot analysis was performed using [KD Validated] YTHDC2 Rabbit polyclonal antibody (STJ11105298) at 1:1000 dilution.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/177942/369971/STJ11105298_1__81591.1713135883.jpg?c=1 "Immunoprecipitation of YTHDC2 in 200 µg extracts from 293T cells using 0. 5 µg [KD Validated] YTHDC2 Rabbit polyclonal antibody (STJ11105298). Western blot analysis was performed using [KD Validated] YTHDC2 Rabbit polyclonal antibody (STJ11105298) at 1:1000 dilution.")