| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-XRCC3 (62-346) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
XRCC3 |
| Gene ID: |
7517 |
| Uniprot ID: |
XRCC3_HUMAN |
| Immunogen Region: |
62-346 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 62-346 of human XRCC3 (NP_001093588.1). |
| Immunogen Sequence: |
ILTALQLHQQKERFPTQHQR LSLGCPVLDALLRGGLPLDG ITELAGRSSAGKTQLALQLC LAVQFPRQHGGLEAGAVYIC TEDAFPHKRLQQLMAQQPRL RTDVPGELLQKLRFGSQIFI EHVADVDTLLECVNKKVPVL LSRGMARLVVIDSVAAPFRC EFDSQASAPRARHLQSLGAT LRELSSAFQSPVLCINQVTE AMEEQGAAHGPLGFWDERVS PALGITWANQLLVRLLADR |
| Function | Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment.the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process.the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. |
| Protein Name | Dna Repair Protein Xrcc3X-Ray Repair Cross-Complementing Protein 3 |
| Database Links | Reactome: R-HSA-5685942Reactome: R-HSA-5693554Reactome: R-HSA-5693568Reactome: R-HSA-5693579 |
| Cellular Localisation | NucleusCytoplasmPerinuclear RegionMitochondrionAccumulates In Discrete Nuclear Foci Prior To Dna DamageAnd These Foci Persist Throughout The Time Course Of Dna Repair |
| Alternative Antibody Names | Anti-Dna Repair Protein Xrcc3 antibodyAnti-X-Ray Repair Cross-Complementing Protein 3 antibodyAnti-XRCC3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
