| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | XPNPEP3 |
| Gene ID: | 63929 |
| Uniprot ID: | XPP3_HUMAN |
| Immunogen Region: | 1-250 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human XPNPEP3 (NP_071381.1). |
| Immunogen Sequence: | MPWLLSAPKLVPAVANVRGL SGCMLCSQRRYSLQPVPERR IPNRYLGQPSPFTHPHLLRP GEVTPGLSQVEYALRRHKLM SLIQKEAQGQSGTDQTVVVL SNPTYYMSNDIPYTFHQDNN FLYLCGFQEPDSILVLQSLP GKQLPSHKAILFVPRRDPSR ELWDGPRSGTDGAIALTGVD EAYTLEEFQHLLPKMKAETN MVWYDWMRPSHAQLHSDYMQ PLTEAKAKSKNKVRGVQQL |
| Tissue Specificity | Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant. |
| Function | Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position. Isoform 1: Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B.the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling. |
| Protein Name | Xaa-Pro Aminopeptidase 3X-Pro Aminopeptidase 3Aminopeptidase P3App3 |
| Cellular Localisation | Isoform 1: MitochondrionCytoplasmMainly MitochondrialTranslocates To The Cytoplasm Following Tnfrsf1b ActivationIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Xaa-Pro Aminopeptidase 3 antibodyAnti-X-Pro Aminopeptidase 3 antibodyAnti-Aminopeptidase P3 antibodyAnti-App3 antibodyAnti-XPNPEP3 antibody |
Information sourced from Uniprot.org