| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | WWP2 |
| Gene ID: | 11060 |
| Uniprot ID: | WWP2_HUMAN |
| Immunogen Region: | 1-270 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human WWP2 (NP_001257383.1). |
| Immunogen Sequence: | MASASSSRAGVALPFEKSQL TLKVVSAKPKVHNRQPRINS YVEVAVDGLPSETKKTGKRI GSSELLWNEIIILNVTAQSH LDLKVWSCHTLRNELLGTAS VNLSNVLKNNGGKMENMQLT LNLQTENKGSVVSGGELTIF LDGPTVDLGNVPNGSALTDG SQLPSRDSSGTAVAPENRHQ PPSTNCFGGRSRTHRHSGAS ARTTPATGEQSPGARSRHRQ PVKNSGHSGLANGTVNDEP |
| Tissue Specificity | Detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. Also detected in spleen and peripheral blood leukocytes. |
| Post Translational Modifications | Autoubiquitinated. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation.in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation.in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2.the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. |
| Protein Name | Nedd4-Like E3 Ubiquitin-Protein Ligase Wwp2 Atrophin-1-Interacting Protein 2 Aip2 Hect-Type E3 Ubiquitin Transferase Wwp2 Ww Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-8948751 Reactome: R-HSA-9013406 Reactome: R-HSA-9013409 Reactome: R-HSA-9013420 Reactome: R-HSA-9013507 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nedd4-Like E3 Ubiquitin-Protein Ligase Wwp2 antibody Anti-Atrophin-1-Interacting Protein 2 antibody Anti-Aip2 antibody Anti-Hect-Type E3 Ubiquitin Transferase Wwp2 antibody Anti-Ww Domain-Containing Protein 2 antibody Anti-WWP2 antibody |
Information sourced from Uniprot.org
