| Short Description : | Rabbit polyclonal WSB1 (182-421) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | WSB1 |
| Gene ID: | 26118 |
| Uniprot ID: | WSB1_HUMAN |
| Immunogen Region: | 182-421 |
| Immunogen Sequence: | GSLILVSASRDKTLRVWDLK DDGNMMKVLRGHQNWVYSCA FSPDSSMLCSVGASKAVFLW NMDKYTMIRKLEGHHHDVVA CDFSPDGALLATASYDTRVY IWDPHNGDILMEFGHLFPPP TPIFAGGANDRWVRSVSFSH DGLHVASLADDKMVRFWRID EDYPVQVAPLSNGLCCAFST DGSVLAAGTHDGSVYFWATP RQVPSLQHLCRMSIRRVMPT QEVQELPIPSKLLEFLSYR |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 182-421 of human WSB1 (NP_056441.6). |
| Function | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation. |
| Protein Name | Wd Repeat And Socs Box-Containing Protein 1Wsb-1Socs Box-Containing Wd Protein Swip-1 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Wd Repeat And Socs Box-Containing Protein 1 antibodyAnti-Wsb-1 antibodyAnti-Socs Box-Containing Wd Protein Swip-1 antibodyAnti-WSB1 antibodyAnti-SWIP1 antibody |
Information sourced from Uniprot.org
