Anti-WDR1 antibody (325-339 aa) [R01-6D6] (STJA0012136)

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STJA0012136-100
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Host: Rabbit
Applications: WB/IHC-F/IHC-P/ICC/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-WDR1 (325-339 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry and Immunofluorescence research applications.
Clonality : Monoclonal
Clone ID : R01-6D6
Conjugation: Unconjugated
Isotype: IgG
Formulation: 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Purification: Affinity Purified
Concentration: 0.3 mg/ml
Dilution Range: WB 1:500-1:1000
IHC 1:50-1:100
IF 1:50-1:200
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: WDR1
Gene ID: 9948
Uniprot ID: WDR1_HUMAN
Immunogen Region: 325-339 aa
Immunogen: A synthetic peptide of human WDR1
Tissue Specificity Expressed in peripheral blood mononuclear cells (at protein level).
Function Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP.the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt.
Protein Name Wd Repeat-Containing Protein 1
Actin-Interacting Protein 1
Aip1
Nori-1
Database Links Reactome: R-HSA-114608
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Podosome
Cell Junction
Alternative Antibody Names Anti-Wd Repeat-Containing Protein 1 antibody
Anti-Actin-Interacting Protein 1 antibody
Anti-Aip1 antibody
Anti-Nori-1 antibody
Anti-WDR1 antibody

Information sourced from Uniprot.org