| Tissue Specificity | Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle. |
| Function | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. |
| Protein Name | Actin-Binding Protein Wasf2Protein Wave-2Verprolin Homology Domain-Containing Protein 2Wiskott-Aldrich Syndrome Protein Family Member 2Wasp Family Protein Member 2 |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-4420097Reactome: R-HSA-5663213Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionLamellipodiumBasolateral Cell MembraneAt The Interface Between The Lamellipodial Actin Meshwork And The Membrane |
| Alternative Antibody Names | Anti-Actin-Binding Protein Wasf2 antibodyAnti-Protein Wave-2 antibodyAnti-Verprolin Homology Domain-Containing Protein 2 antibodyAnti-Wiskott-Aldrich Syndrome Protein Family Member 2 antibodyAnti-Wasp Family Protein Member 2 antibodyAnti-WASF2 antibodyAnti-WAVE2 antibody |
Information sourced from Uniprot.org
