| Post Translational Modifications | Proteolytic cleavage generates 2 forms.T1-TrpRS and T2-TrpRS. |
| Function | Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). Isoform 1: Has no angiostatic activity. T2-TrpRS: Possesses an angiostatic activity but has no aminoacylation activity. Inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Isoform 2: Has an angiostatic activity. |
| Protein Name | Tryptophan--Trna Ligase - CytoplasmicInterferon-Induced Protein 53Ifp53Tryptophanyl-Trna SynthetaseTrprsHwrs Cleaved Into - T1-Trprs - T2-Trprs |
| Database Links | Reactome: R-HSA-379716 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Tryptophan--Trna Ligase - Cytoplasmic antibodyAnti-Interferon-Induced Protein 53 antibodyAnti-Ifp53 antibodyAnti-Tryptophanyl-Trna Synthetase antibodyAnti-Trprs antibodyAnti-Hwrs Cleaved Into - T1-Trprs - T2-Trprs antibodyAnti-WARS1 antibodyAnti-IFI53 antibodyAnti-WARS antibodyAnti-WRS antibody |
Information sourced from Uniprot.org
