| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4841RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:4000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | WARS1 |
| Gene ID: | 7453 |
| Uniprot ID: | SYWC_HUMAN |
| Immunogen Region: | 372-471 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 372-471 of human Tryptophanyl-tRNA synthetase 1 (P23381). |
| Immunogen Sequence: | VNKHAFSGGRDTIEEHRQFG GNCDVDVSFMYLTFFLEDDD KLEQIRKDYTSGAMLTGELK KALIEVLQPLIAEHQARRKE VTDEIVKEFMTPRKLSFDFQ |
| Post Translational Modifications | Proteolytic cleavage generates 2 forms.T1-TrpRS and T2-TrpRS. |
| Function | Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). Isoform 1: Has no angiostatic activity. T2-TrpRS: Possesses an angiostatic activity but has no aminoacylation activity. Inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Isoform 2: Has an angiostatic activity. |
| Protein Name | Tryptophan--Trna Ligase - Cytoplasmic Interferon-Induced Protein 53 Ifp53 Tryptophanyl-Trna Synthetase Trprs Hwrs Cleaved Into - T1-Trprs - T2-Trprs |
| Database Links | Reactome: R-HSA-379716 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Tryptophan--Trna Ligase - Cytoplasmic antibody Anti-Interferon-Induced Protein 53 antibody Anti-Ifp53 antibody Anti-Tryptophanyl-Trna Synthetase antibody Anti-Trprs antibody Anti-Hwrs Cleaved Into - T1-Trprs - T2-Trprs antibody Anti-WARS1 antibody Anti-IFI53 antibody Anti-WARS antibody Anti-WRS antibody |
Information sourced from Uniprot.org