Western blot analysis of various lysates using Tryptophanyl-tRNA synthetase 1 Rabbit monoclonal antibody (STJ11102087) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-WARS antibody (3-98) [S7MR] (STJ11102087)

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STJ11102087
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : S7MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: WARS1
Gene ID: 7453
Uniprot ID: SYWC_HUMAN
Immunogen Region: 3-98
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 3-98 of human Tryptophanyl-tRNA synthetase 1 (P23381).
Immunogen Sequence: NSEPASLLELFNSIATQGEL VRSLKAGNASKDEIDSAVKM LVSLKMSYKAAAGEDYKADC PPGNPAPTSNHGPDATEAEE DFVDPWTVQTSSAKGI
Post Translational Modifications Proteolytic cleavage generates 2 forms.T1-TrpRS and T2-TrpRS.
Function Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). Isoform 1: Has no angiostatic activity. T2-TrpRS: Possesses an angiostatic activity but has no aminoacylation activity. Inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Isoform 2: Has an angiostatic activity.
Protein Name Tryptophan--Trna Ligase - Cytoplasmic
Interferon-Induced Protein 53
Ifp53
Tryptophanyl-Trna Synthetase
Trprs
Hwrs Cleaved Into - T1-Trprs - T2-Trprs
Database Links Reactome: R-HSA-379716
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Tryptophan--Trna Ligase - Cytoplasmic antibody
Anti-Interferon-Induced Protein 53 antibody
Anti-Ifp53 antibody
Anti-Tryptophanyl-Trna Synthetase antibody
Anti-Trprs antibody
Anti-Hwrs Cleaved Into - T1-Trprs - T2-Trprs antibody
Anti-WARS1 antibody
Anti-IFI53 antibody
Anti-WARS antibody
Anti-WRS antibody

Information sourced from Uniprot.org

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