| Tissue Specificity | Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart. |
| Post Translational Modifications | Deubiquitinated by USP37.leading to stabilization. |
| Function | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. |
| Protein Name | Wings Apart-Like Protein HomologFriend Of Ebna2 ProteinWapl Cohesin Release Factor |
| Database Links | Reactome: R-HSA-2467813Reactome: R-HSA-2468052Reactome: R-HSA-2470946Reactome: R-HSA-2500257 |
| Cellular Localisation | Isoform 2: NucleusNucleusChromosomeCytoplasmAssociates With Chromatin Through The Cohesin Complex During InterphaseReleased In The Cytoplasm From Nuclear Envelope Breakdown Until AnaphaseIt Reaccumulates In Nucleus At Telophase |
| Alternative Antibody Names | Anti-Wings Apart-Like Protein Homolog antibodyAnti-Friend Of Ebna2 Protein antibodyAnti-Wapl Cohesin Release Factor antibodyAnti-WAPL antibodyAnti-FOE antibodyAnti-KIAA0261 antibodyAnti-WAPAL antibody |
Information sourced from Uniprot.org
