| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | VPS54 |
| Gene ID: | 51542 |
| Uniprot ID: | VPS54_HUMAN |
| Immunogen Region: | 420-720 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-720 of human VPS54 (NP_001005739.1). |
| Immunogen Sequence: | VVKLADQMRMLNFPQWFDLL KDIFSKFTIFLQRVKATLNI IHSVVLSVLDKNQRTRELEE ISQQKNAAKDNSLDTEVAYL IHEGMFISDAFGEGELTPIA VDTTSQRNASPNSEPCSSDS VSEPECTTDSSSSKEHTSSS AIPGGVDIMVSEDMKLTDSE LGKLANNIQELLYSASDICH DRAVKFLMSRAKDGFLEKLN SMEFITLSRLMETFILDTEQ ICGRKSTSLLGALQSQAIK |
| Function | Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling. |
| Protein Name | Vacuolar Protein Sorting-Associated Protein 54Hepatocellular Carcinoma Protein 8Tumor Antigen Hom-Hcc-8Tumor Antigen Slp-8p |
| Database Links | Reactome: R-HSA-6811440 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi NetworkMembraneAssociates With Membranes In An Eipr1-Independent Manner |
| Alternative Antibody Names | Anti-Vacuolar Protein Sorting-Associated Protein 54 antibodyAnti-Hepatocellular Carcinoma Protein 8 antibodyAnti-Tumor Antigen Hom-Hcc-8 antibodyAnti-Tumor Antigen Slp-8p antibodyAnti-VPS54 antibodyAnti-HCC8 antibody |
Information sourced from Uniprot.org