| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Vacuolar protein sorting-associated protein 41 homolog is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
VPS41 |
| Gene ID: |
27072 |
| Uniprot ID: |
VPS41_HUMAN |
| Specificity: |
This antibody detects endogenous levels of VPS41 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human VPS41 |
| Function | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo. Required for fusion of autophagosomes with lysosomes. Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion. Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS. Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex. May play a role in HOPS-independent function in the regulated secretory pathway. |
| Protein Name | Vacuolar Protein Sorting-Associated Protein 41 HomologS53 |
| Database Links | Reactome: R-HSA-9754560 |
| Cellular Localisation | Endosome MembranePeripheral Membrane ProteinLate Endosome MembraneEarly Endosome MembraneLysosome MembraneGolgi ApparatusTrans-Golgi NetworkCytoplasmic VesicleClathrin-Coated VesicleCytoplasmCytosol(Microbial Infection) Sequestrated At The Late Endosome By Sars Coronavirus-2/Sars-Cov-2 Orf3a Protein |
| Alternative Antibody Names | Anti-Vacuolar Protein Sorting-Associated Protein 41 Homolog antibodyAnti-S53 antibodyAnti-VPS41 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
