| Tissue Specificity | Expressed at the mRNA level in kidney, liver, pancreas, and placenta. Lower levels of expression are found in heart, skeletal muscle, brain and lung. |
| Function | Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses. |
| Protein Name | Vacuolar Protein-Sorting-Associated Protein 25Hvps25Dermal Papilla-Derived Protein 9Ell-Associated Protein Of 20 KdaEscrt-Ii Complex Subunit Vps25 |
| Database Links | Reactome: R-HSA-917729Reactome: R-HSA-9610379 |
| Cellular Localisation | CytoplasmEndosome MembraneNucleusNucleoplasmDistributes Diffusely Throughout The Cytoplasm And NucleoplasmBut Exhibits A Punctate Distribution On Coexpression With Chmp6 |
| Alternative Antibody Names | Anti-Vacuolar Protein-Sorting-Associated Protein 25 antibodyAnti-Hvps25 antibodyAnti-Dermal Papilla-Derived Protein 9 antibodyAnti-Ell-Associated Protein Of 20 Kda antibodyAnti-Escrt-Ii Complex Subunit Vps25 antibodyAnti-VPS25 antibodyAnti-DERP9 antibodyAnti-EAP20 antibody |
Information sourced from Uniprot.org
