STJ71298 (0. 03µg/ml) staining of Human Lung lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-Vitamin D-binding protein/GC antibody (Internal) (STJ71298)

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STJ71298-100
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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Goat polyclonal antibody anti-Vitamin D-binding protein/GC (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: Peptide ELISA: antibody detection limit dilution 1:2000.
WB: Approx 56kDa band observed in Human Lung lysates (calculated MW of 52.9kDa according to NP_000574.2). The observed molecular weight corresponds to earlier findings in literature with di
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: GC
Gene ID: 2638
Uniprot ID: VTDB_HUMAN
Immunogen Region: Internal
Accession Number: NP_000574.2
Immunogen Sequence: CDNLSTKNSKFED
Post Translational Modifications Allele GC*1S is O-glycosylated at Thr-436. The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated. The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated.
Function Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Protein Name Vitamin D-Binding Protein
Dbp
Vdb
Gc Protein-Derived Macrophage Activating Factor
Gc-Maf
Gcmaf
Gc-Globulin
Group-Specific Component
Gc
Vitamin D-Binding Protein-Macrophage Activating Factor
Dbp-Maf
Database Links Reactome: R-HSA-196791
Cellular Localisation Secreted
Alternative Antibody Names Anti-Vitamin D-Binding Protein antibody
Anti-Dbp antibody
Anti-Vdb antibody
Anti-Gc Protein-Derived Macrophage Activating Factor antibody
Anti-Gc-Maf antibody
Anti-Gcmaf antibody
Anti-Gc-Globulin antibody
Anti-Group-Specific Component antibody
Anti-Gc antibody
Anti-Vitamin D-Binding Protein-Macrophage Activating Factor antibody
Anti-Dbp-Maf antibody
Anti-GC antibody

Information sourced from Uniprot.org

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