Anti-VIRMA antibody (1400-1700) (STJ118641)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KIAA1429 (1400-1700) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000IHC-P:1:50-1:200IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VIRMA |
| Gene ID | 25962 |
| Uniprot ID | VIR_HUMAN |
| Immunogen Region | 1400-1700 |
| Immunogen Sequence | FMRQILNSDTIGCCGDDNGL MEVEGAHTSRTMSINAAELK QLLQSKEESPENLFLELEKL VLEHSKDDDNLDSLLDSVVG LKQMLESSGDPLPLSDQDVE PVLSAPESLQNLFNNRTAYV LADVMDDQLKSMWFTPFQAE EIDTDLDLVKVDLIELSEKC CSDFDLHSELERSFLSEPSS PGRTKTTKGFKLGKHKHETF ITSSGKSEYIEPAKRAHVVP PPRGRGRGGFGQGIRPHDI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1700 of human KIAA1429 (NP_056311.2). |
Additional Info
| Function | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA). |
| Protein Name | Protein Virilizer Homolog |
| Database Links | |
| Cellular Localisation | Nucleus SpeckleNucleusNucleoplasmCytoplasmMainly Nuclear With Some Fraction Located In The CytoplasmZc3h13 Is Required To Anchor Component Of The Macom SubcomplexSuch As VirmaIn The Nucleus |
| Alternative Antibody Names | Anti-Protein Virilizer Homolog antibodyAnti-VIRMA antibodyAnti-KIAA1429 antibodyAnti-MSTP054 antibody |
Information sourced from Uniprot.org