| Function | G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of potency PACAP38 = VIP > PACAP27. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May be coupled to phospholipase C. |
| Protein Name | Vasoactive Intestinal Polypeptide Receptor 2Vip-R-2Helodermin-Preferring Vip ReceptorPituitary Adenylate Cyclase-Activating Polypeptide Type Iii ReceptorPacap Type Iii ReceptorPacap-R-3Pacap-R3Vpac2 ReceptorVpac2r |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-420092 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Vasoactive Intestinal Polypeptide Receptor 2 antibodyAnti-Vip-R-2 antibodyAnti-Helodermin-Preferring Vip Receptor antibodyAnti-Pituitary Adenylate Cyclase-Activating Polypeptide Type Iii Receptor antibodyAnti-Pacap Type Iii Receptor antibodyAnti-Pacap-R-3 antibodyAnti-Pacap-R3 antibodyAnti-Vpac2 Receptor antibodyAnti-Vpac2r antibodyAnti-VIPR2 antibodyAnti-VIP2R antibody |
Information sourced from Uniprot.org