Anti-VIPAS39 antibody (1-220) (STJ26331)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal VIPAS39 (1-220) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VIPAS39 |
| Gene ID | 63894 |
| Uniprot ID | SPE39_HUMAN |
| Immunogen Region | 1-220 |
| Immunogen Sequence | MNRTKGDEEEYWNSSKFKAF TFDDEDDELSQLKESKRAVN SLRDFVDDDDDDDLERVSWS GEPVGSISWSIRETAGNSGS THEGREQLKSRNSFSSYAQL PKPTSTYSLSSFFRGRTRPG SFQSLSDALSDTPAKSYAPE LGRPKGEYRDYSNDWSPSDT VRRLRKGKVCSLERFRSLQD KLQLLEEAVSMHDGNVITAV LIFLKRTLSKEILFRELEVR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human VIPAS39 (NP_071350.2). |
Additional Info
| Function | Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes.the functions seems to be independent of VPS33B. May play a role in vesicular trafficking during spermatogenesis. May be involved in direct or indirect transcriptional regulation of E-cadherin. |
| Protein Name | Spermatogenesis-Defective Protein 39 HomologHspe-39Vps33b-Interacting Protein In Apical-Basolateral Polarity RegulatorVps33b-Interacting Protein In Polarity And Apical Restriction |
| Database Links | |
| Cellular Localisation | CytoplasmCytoplasmic VesicleEarly EndosomeRecycling EndosomeLate EndosomeColocalizes In Clusters With Vps33b At Cytoplasmic Organelles |
| Alternative Antibody Names | Anti-Spermatogenesis-Defective Protein 39 Homolog antibodyAnti-Hspe-39 antibodyAnti-Vps33b-Interacting Protein In Apical-Basolateral Polarity Regulator antibodyAnti-Vps33b-Interacting Protein In Polarity And Apical Restriction antibodyAnti-VIPAS39 antibodyAnti-C14orf133 antibodyAnti-SPE39 antibodyAnti-VIPAR antibody |
Information sourced from Uniprot.org