| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Vascular Endothelial Growth Factor C (112-227) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
VEGFC |
| Gene ID: |
7424 |
| Uniprot ID: |
VEGFC_HUMAN |
| Immunogen Region: |
112-227 |
| Immunogen: |
Recombinant Protein corresponding to a sequence within amino acids 112-227 of human VEGFC (NP_005420.1). |
| Immunogen Sequence: |
AHYNTEILKSIDNEWRKTQC MPREVCIDVGKEFGVATNTF FKPPCVSVYRCGGCCNSEGL QCMNTSTSYLSKTLFEITVP LSQGPKPVTISFANHTSCRC MSKLDVYRQVHSIIRR |
| Tissue Specificity | Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. |
| Post Translational Modifications | Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. |
| Function | Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. |
| Protein Name | Vascular Endothelial Growth Factor CVegf-CFlt4 LigandFlt4-LVascular Endothelial Growth Factor-Related ProteinVrp |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-194313Reactome: R-HSA-195399 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Vascular Endothelial Growth Factor C antibodyAnti-Vegf-C antibodyAnti-Flt4 Ligand antibodyAnti-Flt4-L antibodyAnti-Vascular Endothelial Growth Factor-Related Protein antibodyAnti-Vrp antibodyAnti-VEGFC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
