Anti-VDR antibody (150-250) [PTR2542] (STJA0006257)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenSynthesized peptide derived from human Vitamin D Receptor AA range: 150-250
General Information
| Short Description | Mouse monoclonal anti-Vitamin D3 receptor (150-250) for use in WB, ELISA and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PTR2542 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | Purified using Protein G purification. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS pH7.4 containing 50% Glycerol and 0.03% Proclin 300. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VDR |
| Gene ID | 7421 |
| Uniprot ID | VDR_HUMAN |
| Immunogen | Synthesized peptide derived from human Vitamin D Receptor AA range: 150-250 |
| Immunogen Region | 150-250 |
| Specificity | This antibody detects endogenous levels of Vitamin D Receptor at Human |
Additional Info
| Post Translational Modifications | Ubiquitinated by UBR5, leading to its degradation: UBR5 specifically recognizes and binds ligand-bound VDR when it is not associated with coactivators (NCOAs). In presence of NCOAs, the UBR5-degron is not accessible, preventing its ubiquitination and degradation. |
| Function | Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis. Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites. |
| Protein Name | Vitamin D3 ReceptorVdr1 -25-Dihydroxyvitamin D3 ReceptorNuclear Receptor Subfamily 1 Group I Member 1 |
| Database Links | Reactome: R-HSA-196791Reactome: R-HSA-383280Reactome: R-HSA-4090294 |
| Cellular Localisation | NucleusCytoplasmLocalizes Mainly To The NucleusTranslocated Into The Nucleus Via Both Ligand-Dependent And Ligand-Independent PathwaysLigand-Independent Nuclear Translocation Is Mediated By Ipo4 |
| Alternative Antibody Names | Anti-Vitamin D3 Receptor antibodyAnti-Vdr antibodyAnti-1 -25-Dihydroxyvitamin D3 Receptor antibodyAnti-Nuclear Receptor Subfamily 1 Group I Member 1 antibodyAnti-VDR antibodyAnti-NR1I1 antibody |
Information sourced from Uniprot.org