Anti-USP51 antibody (STJ191581)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Ubiquitin carboxyl-terminal hydrolase 51 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | USP51 |
| Gene ID | 158880 |
| Uniprot ID | UBP51_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | UBP51 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Functions in DNA double-strand break repair also by mediating the deubiquitination and subsequent stabilization of DGCR8, leading to the recruitment of DGCR8 binding partners to double strand breaks such as RNF168 or MDC1. In addition, promotes the deubiquitination and stabilization of the transcriptional repressor ZEB1. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 51Deubiquitinating Enzyme 51Ubiquitin Thioesterase 51Ubiquitin-Specific-Processing Protease 51 |
| Database Links | |
| Cellular Localisation | ChromosomeUpon Dna DamageChromatin-Bound Usp51 Disassociates From Chromatin Immediately Following Dna Damage And Reassociates With Chromatin Following Dna Repair |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 51 antibodyAnti-Deubiquitinating Enzyme 51 antibodyAnti-Ubiquitin Thioesterase 51 antibodyAnti-Ubiquitin-Specific-Processing Protease 51 antibodyAnti-USP51 antibody |
Information sourced from Uniprot.org