| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Ubiquitin carboxyl-terminal hydrolase 51 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | USP51 |
| Gene ID: | 158880 |
| Uniprot ID: | UBP51_HUMAN |
| Specificity: | UBP51 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Function | Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Functions in DNA double-strand break repair also by mediating the deubiquitination and subsequent stabilization of DGCR8, leading to the recruitment of DGCR8 binding partners to double strand breaks such as RNF168 or MDC1. In addition, promotes the deubiquitination and stabilization of the transcriptional repressor ZEB1. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 51 Deubiquitinating Enzyme 51 Ubiquitin Thioesterase 51 Ubiquitin-Specific-Processing Protease 51 |
| Cellular Localisation | Chromosome Upon Dna Damage Chromatin-Bound Usp51 Disassociates From Chromatin Immediately Following Dna Damage And Reassociates With Chromatin Following Dna Repair |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 51 antibody Anti-Deubiquitinating Enzyme 51 antibody Anti-Ubiquitin Thioesterase 51 antibody Anti-Ubiquitin-Specific-Processing Protease 51 antibody Anti-USP51 antibody |
Information sourced from Uniprot.org
