| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
USP48 |
| Gene ID: |
84196 |
| Uniprot ID: |
UBP48_HUMAN |
| Immunogen Region: |
1-300 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human USP48 (NP_115612.4). |
| Immunogen Sequence: |
MAPRLQLEKAAWRWAETVRP EEVSQEHIETAYRIWLEPCI RGVCRRNCKGNPNCLVGIGE HIWLGEIDENSFHNIDDPNC ERRKKNSFVGLTNLGATCYV NTFLQVWFLNLELRQALYLC PSTCSDYMLGDGIQEEKDYE PQTICEHLQYLFALLQNSNR RYIDPSGFVKALGLDTGQQQ DAQEFSKLFMSLLEDTLSKQ KNPDVRNIVQQQFCGEYAYV TVCNQCGRESKLLSKFYEL |
| Tissue Specificity | Widely expressed. Expressed in the fetal inner ear. |
| Function | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins. Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB and thereby extending its stability. In the context of H. pylori infection, stabilizes nuclear RELA through deubiquitination, thereby promoting the transcriptional activity of RELA to prolong TNFAIP3 de novo synthesis. Consequently, TNFAIP3 suppresses caspase activity and apoptotic cell death. Functions also in the modulation of the ciliary and synaptic transport as well as cytoskeleton organization, which are key for photoreceptor function and homeostasis. To achieve this, stabilizes the levels of the retinal degeneration-associated proteins ARL3 and UNC119 using distinct mechanisms. Plays a positive role in pyroptosis by stabilizing gasdermin E/GSDME through removal of its 'Lys-48'-linked ubiquitination. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 48Deubiquitinating Enzyme 48Ubiquitin Thioesterase 48Ubiquitin-Specific Peptidase 48Ubiquitin-Specific Protease 48Ubiquitin-Specific-Processing Protease 48 |
| Database Links | Reactome: R-HSA-5689880 |
| Cellular Localisation | CytoplasmNucleusCell ProjectionCilium |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 48 antibodyAnti-Deubiquitinating Enzyme 48 antibodyAnti-Ubiquitin Thioesterase 48 antibodyAnti-Ubiquitin-Specific Peptidase 48 antibodyAnti-Ubiquitin-Specific Protease 48 antibodyAnti-Ubiquitin-Specific-Processing Protease 48 antibodyAnti-USP48 antibodyAnti-USP31 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
