| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Ubiquitin carboxyl-terminal hydrolase 21 (50-100 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | USP21 |
| Gene ID: | 27005 |
| Uniprot ID: | UBP21_HUMAN |
| Immunogen Region: | 50-100 aa |
| Specificity: | This antibody detects endogenous levels of UBP21 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human UBP21 at the amino acid range 50-100 |
| Function | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Deubiquitinates BAZ2A/TIP5 leading to its stabilization. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 21 Deubiquitinating Enzyme 21 Ubiquitin Thioesterase 21 Ubiquitin-Specific-Processing Protease 21 |
| Database Links | Reactome: R-HSA-5357786 Reactome: R-HSA-5357905 Reactome: R-HSA-5357956 Reactome: R-HSA-5689880 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 21 antibody Anti-Deubiquitinating Enzyme 21 antibody Anti-Ubiquitin Thioesterase 21 antibody Anti-Ubiquitin-Specific-Processing Protease 21 antibody Anti-USP21 antibody Anti-USP23 antibody Anti-PP1490 antibody |
Information sourced from Uniprot.org