Anti-ASIC3 antibody (50-100 aa) (STJ13100021)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 50-100 of rat ASIC3 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse.
General Information
| Short Description | Rabbit polyclonal anti-ASIC3 (50-100 aa) for use in IHC and WB in Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Asic3 |
| Gene ID | 171209 |
| Uniprot ID | ASIC3_MOUSE |
| Immunogen | A synthetic peptide from aa region 50-100 of rat ASIC3 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse. |
| Immunogen Region | 50-100 aa |
| Specificity | Specific for ASIC3. |
Additional Info
| Function | Forms voltage-independent, pH-gated heterotrimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system. Upon extracellular acidification, these channels generate a biphasic current with a fast inactivating and a slow sustained phase. ASIC3 is more sensitive to protons and gates between closed, open, and desensitized states faster than other ASICs. Displays high selectivity for sodium ions but can also permit the permeation of other cations. As a neuronal acid sensor, probably contributes to mechanoreception, acid nociception, and heat nociception. By forming heterotrimeric channels with ASIC2, generates a biphasic current with a fast inactivating and a slow sustained phase, which in sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissues. |
| Protein Name | Acid-Sensing Ion Channel 3Asic3Amiloride-Sensitive Cation Channel 3Dorsal Root AsicDrasic |
| Database Links | Reactome: R-MMU-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmPreferentially Expressed At The Plasma Membrane Of The Soma And Cellular Processes Of NeuronsIn Part Cytoplasmic In Cochlea CellsLocalized In Specialized Sensory Nerve Endings |
| Alternative Antibody Names | Anti-Acid-Sensing Ion Channel 3 antibodyAnti-Asic3 antibodyAnti-Amiloride-Sensitive Cation Channel 3 antibodyAnti-Dorsal Root Asic antibodyAnti-Drasic antibodyAnti-Asic3 antibodyAnti-Accn3 antibodyAnti-Drasic antibody |
Information sourced from Uniprot.org