| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
USP21 |
| Gene ID: |
27005 |
| Uniprot ID: |
UBP21_HUMAN |
| Immunogen Region: |
1-18 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human USP21 (NP_036607.3). |
| Immunogen Sequence: |
MPQASEHRLGRTREPPVNIQ PRVGSKLPFAPRARSKERRN PASGPNPMLRPLPPRPGLPD ERLKKLELGRGRTSGPRPRG PLRADHGVPLPGSPPPTVAL |
| Tissue Specificity | Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung. |
| Function | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Deubiquitinates BAZ2A/TIP5 leading to its stabilization. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 21Deubiquitinating Enzyme 21Ubiquitin Thioesterase 21Ubiquitin-Specific-Processing Protease 21 |
| Database Links | Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5689880 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 21 antibodyAnti-Deubiquitinating Enzyme 21 antibodyAnti-Ubiquitin Thioesterase 21 antibodyAnti-Ubiquitin-Specific-Processing Protease 21 antibodyAnti-USP21 antibodyAnti-USP23 antibodyAnti-PP1490 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
