| Host: |
Rabbit |
| Applications: |
WB/IP/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
S6MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
USP14 |
| Gene ID: |
9097 |
| Uniprot ID: |
UBP14_HUMAN |
| Immunogen Region: |
371-473 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 371-473 of human USP14 (P54578). |
| Immunogen Sequence: |
RSKFKDLEDKKVNQQPNTSD KKSSPQKEVKYEPFSFADDI GSNNCGYYDLQAVLTHQGRS SSSGHYVSWVKRKQDEWIKF DDDKVSIVTPEDILRLSGGG DWH |
| Function | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation. Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 14Deubiquitinating Enzyme 14Ubiquitin Thioesterase 14Ubiquitin-Specific-Processing Protease 14 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-9758274 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 14 antibodyAnti-Deubiquitinating Enzyme 14 antibodyAnti-Ubiquitin Thioesterase 14 antibodyAnti-Ubiquitin-Specific-Processing Protease 14 antibodyAnti-USP14 antibodyAnti-TGT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
