| Function | Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex.may act by deubiquitinating components of the PRC1-like complex. Promotes cell proliferation by deubiquitinating phosphorylated E2F1. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 11Deubiquitinating Enzyme 11Ubiquitin Thioesterase 11Ubiquitin-Specific-Processing Protease 11 |
| Cellular Localisation | NucleusCytoplasmChromosomePredominantly NuclearAssociates With Chromatin |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 11 antibodyAnti-Deubiquitinating Enzyme 11 antibodyAnti-Ubiquitin Thioesterase 11 antibodyAnti-Ubiquitin-Specific-Processing Protease 11 antibodyAnti-USP11 antibodyAnti-UHX1 antibody |
Information sourced from Uniprot.org
