Anti-USH1C antibody (STJA0008197)

SKU:
STJA0008197

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Harmonin is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: USH1C
Gene ID: 10083
Uniprot ID: USH1C_HUMAN
Specificity: This antibody detects endogenous levels of Harmonin at Human, Mouse
Immunogen: Synthesized peptide derived from human Harmonin
Function Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips.
Protein Name Harmonin
Antigen Ny-Co-38/Ny-Co-37
Autoimmune Enteropathy-Related Antigen Aie-75
Protein Pdz-73
Renal Carcinoma Antigen Ny-Ren-3
Usher Syndrome Type-1c Protein
Database Links Reactome: R-HSA-9662360
Reactome: R-HSA-9662361
Cellular Localisation Cytoplasm
Cytosol
Cytoskeleton
Cell Projection
Microvillus
Colocalizes With F-Actin
Detected At The Tip Of Cochlear Hair Cell Stereocilia
Enriched In Microvilli Of The Intestinal Brush Border
Alternative Antibody Names Anti-Harmonin antibody
Anti-Antigen Ny-Co-38/Ny-Co-37 antibody
Anti-Autoimmune Enteropathy-Related Antigen Aie-75 antibody
Anti-Protein Pdz-73 antibody
Anti-Renal Carcinoma Antigen Ny-Ren-3 antibody
Anti-Usher Syndrome Type-1c Protein antibody
Anti-USH1C antibody
Anti-AIE75 antibody

Information sourced from Uniprot.org

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