| Post Translational Modifications | Autophosphorylated. Autophosphorylation is blocked by interaction with SUFU. |
| Function | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. |
| Protein Name | Serine/Threonine-Protein Kinase Ulk3Unc-51-Like Kinase 3 |
| Database Links | Reactome: R-HSA-5632684 |
| Cellular Localisation | CytoplasmLocalizes To Pre-Autophagosomal Structure During Cellular Senescence |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Ulk3 antibodyAnti-Unc-51-Like Kinase 3 antibodyAnti-ULK3 antibody |
Information sourced from Uniprot.org
