| Tissue Specificity | Mostly detected in several tissues, including the thymus, spleen, lung, adrenal gland, and ovary. In addition, found in several tissues in the brain (cerebellum, hippocampus, and cerebral cortex). |
| Post Translational Modifications | May be autoubiquitinated.which may lead to proteasomal degradation. Phosphorylated. Phosphorylation may be mediated by CDK2. Autosumoylated. |
| Function | E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair. Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them. This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression. Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thus inducing G1 arrest. Ubiquitinates also PCNP leading to its degradation by the proteasome. Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation. Promotes also DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation. Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation. |
| Protein Name | E3 Ubiquitin-Protein Ligase Uhrf2NirfNp95-Like Ring Finger ProteinNuclear Protein 97Nuclear Zinc Finger Protein Np97Ring-Type E3 Ubiquitin Transferase Uhrf2Ubiquitin-Like Phd And Ring Finger Domain-Containing Protein 2Ubiquitin-Like-Containing Phd And Ring Finger Domains Protein 2 |
| Database Links | Reactome: R-MMU-3899300 |
| Cellular Localisation | NucleusChromosomeEnriched At Genomic Loci That Are Enriched For 5-Hydroxy-Methylcytosine (5hmc) |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Uhrf2 antibodyAnti-Nirf antibodyAnti-Np95-Like Ring Finger Protein antibodyAnti-Nuclear Protein 97 antibodyAnti-Nuclear Zinc Finger Protein Np97 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Uhrf2 antibodyAnti-Ubiquitin-Like Phd And Ring Finger Domain-Containing Protein 2 antibodyAnti-Ubiquitin-Like-Containing Phd And Ring Finger Domains Protein 2 antibodyAnti-Uhrf2 antibodyAnti-Nirf antibody |
Information sourced from Uniprot.org
