| Tissue Specificity | Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). |
| Function | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively. Does not ubiquitinate proteins that are acetylated at the N-terminus. In contrast, it strongly binds methylated N-degrons. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. |
| Protein Name | E3 Ubiquitin-Protein Ligase Ubr1N-Recognin-1Ubiquitin-Protein Ligase E3-Alpha-1Ubiquitin-Protein Ligase E3-Alpha-I |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Ubr1 antibodyAnti-N-Recognin-1 antibodyAnti-Ubiquitin-Protein Ligase E3-Alpha-1 antibodyAnti-Ubiquitin-Protein Ligase E3-Alpha-I antibodyAnti-UBR1 antibody |
Information sourced from Uniprot.org
