• Immunohistochemistry of mouse muscle with Anti-UBR1 primary antibody (STJ503452) at 1:100 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-UBR1 antibody (1260-1500) (STJ503452)

SKU:
STJ503452-100

€551.88
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-UBR1 (1260-1500) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.68-0.70 µg/µl
Dilution Range: WB: 1:500
DB: 1:4, 000
ELISA: 1:4, 000
IP: 1:150
IHC: 1:50-:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: UBR1
Gene ID: 197131
Uniprot ID: UBR1_HUMAN
Immunogen Region: 1260-1500
Immunogen: Synthetic peptide taken within amino acid region 1260-1500 on human UBR1 protein.
Tissue Specificity Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Protein Name E3 Ubiquitin-Protein Ligase Ubr1
N-Recognin-1
Ring-Type E3 Ubiquitin Transferase Ubr1
Ubiquitin-Protein Ligase E3-Alpha-1
Ubiquitin-Protein Ligase E3-Alpha-I
Database Links Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Cytosol
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Ubr1 antibody
Anti-N-Recognin-1 antibody
Anti-Ring-Type E3 Ubiquitin Transferase Ubr1 antibody
Anti-Ubiquitin-Protein Ligase E3-Alpha-1 antibody
Anti-Ubiquitin-Protein Ligase E3-Alpha-I antibody
Anti-UBR1 antibody

Information sourced from Uniprot.org

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