Anti-Ubinuclein 1/ubinuclein 2 antibody (Internal) (STJ72829)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Ubinuclein 1/ubinuclein 2 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig/Cow/Zebrafish |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 120kDa band observed in lysates of cell line MOLT4 (calculated MW of 122kDa according to NP_058632.2). Recommended concentration: 1-3ยตg/ml. An additional band of unknown identi |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | UBN1 |
| Gene ID | 29855 |
| Uniprot ID | UBN1_HUMAN |
| Accession Number | NP_058632.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | DNSEAYDELVPASLT |
| Specificity | Reported variants represent identical protein: NP_058632.2, NP_001072982.1. |
Additional Info
| Function | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. |
| Protein Name | Ubinuclein-1Hira-Binding ProteinProtein Vt4Ubiquitously Expressed Nuclear Protein |
| Database Links | Reactome: R-HSA-2559584 |
| Cellular Localisation | NucleusNucleoplasmPml BodyCell JunctionTight JunctionLocalized As A Nuclear Speckled-Like Pattern In Proliferating Primary FibroblastsColocalizes With HiraPml And Sp100 In Pml Bodies Of Senescent CellsColocalizes With Tjp1 And Cldn1Detected Along The Upper Granular Cell Layer Of EpidermisWhen OverexpressedAccumulates In The Nucleus In Cells Showing Defective Cytokinesis |
| Alternative Antibody Names | Anti-Ubinuclein-1 antibodyAnti-Hira-Binding Protein antibodyAnti-Protein Vt4 antibodyAnti-Ubiquitously Expressed Nuclear Protein antibodyAnti-UBN1 antibody |
Information sourced from Uniprot.org