| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UBE2V2 |
| Gene ID: | 7336 |
| Uniprot ID: | UB2V2_HUMAN |
| Immunogen Region: | 1-145 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human UBE2V2 (NP_003341.1). |
| Immunogen Sequence: | MAVSTGVKVPRNFRLLEELE EGQKGVGDGTVSWGLEDDED MTLTRWTGMIIGPPRTNYEN RIYSLKVECGPKYPEAPPSV RFVTKINMNGINNSSGMVDA RSIPVLAKWQNSYSIKVVLQ ELRRLMMSKENMKLPQPPEG QTYNN |
| Tissue Specificity | Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues. |
| Function | Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 Variant 2Ddvit 1Enterocyte Differentiation-Associated Factor 1Edaf-1Enterocyte Differentiation-Promoting Factor 1Edpf-1Mms2 HomologVitamin D3-Inducible Protein |
| Database Links | Reactome: R-HSA-5693565Reactome: R-HSA-5693571Reactome: R-HSA-5693607Reactome: R-HSA-5696395Reactome: R-HSA-69473Reactome: R-HSA-8866654Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-Ubiquitin-Conjugating Enzyme E2 Variant 2 antibodyAnti-Ddvit 1 antibodyAnti-Enterocyte Differentiation-Associated Factor 1 antibodyAnti-Edaf-1 antibodyAnti-Enterocyte Differentiation-Promoting Factor 1 antibodyAnti-Edpf-1 antibodyAnti-Mms2 Homolog antibodyAnti-Vitamin D3-Inducible Protein antibodyAnti-UBE2V2 antibodyAnti-MMS2 antibodyAnti-UEV2 antibody |
Information sourced from Uniprot.org
