| Tissue Specificity | Widely expressed (at protein level). |
| Post Translational Modifications | The acetylation of Met-1 increases affinity for DCUN1D3 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins. |
| Function | Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. Together with the E3 ubiquitin ligase RNF7/RBX2, specifically neddylates cullin-5 (CUL5). Does not neddylate CUL1, CUL2, CUL3, CUL4A or CUL4B. Mediates neddylation of the CUL9-RBX1 complex. (Microbial infection) Following infection by HIV-1 virus, participates to HIV-1 Vif protein-mediated ubiquitination and degradation of APOBEC3G by mediating neddylation of cullin-5 (CUL5). |
| Protein Name | Nedd8-Conjugating Enzyme Ube2fNedd8 Carrier Protein Ube2fNedd8 Protein Ligase Ube2fNedd8-Conjugating Enzyme 2Ring-Type E3 Nedd8 Transferase Ube2fUbiquitin-Conjugating Enzyme E2 F |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Nedd8-Conjugating Enzyme Ube2f antibodyAnti-Nedd8 Carrier Protein Ube2f antibodyAnti-Nedd8 Protein Ligase Ube2f antibodyAnti-Nedd8-Conjugating Enzyme 2 antibodyAnti-Ring-Type E3 Nedd8 Transferase Ube2f antibodyAnti-Ubiquitin-Conjugating Enzyme E2 F antibodyAnti-UBE2F antibodyAnti-NCE2 antibody |
Information sourced from Uniprot.org
