| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Ubiquitin-associated and SH3 domain-containing protein A (311-360 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000ELISA 1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UBASH3A |
| Gene ID: | 53347 |
| Uniprot ID: | UBS3A_HUMAN |
| Immunogen Region: | 311-360 aa |
| Specificity: | TULA Polyclonal Antibody detects endogenous levels of TULA protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human UBASH3A at the amino acid range 311-360 |
| Function | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligible protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. |
| Protein Name | Ubiquitin-Associated And Sh3 Domain-Containing Protein ACbl-Interacting Protein 4Clip4Suppressor Of T-Cell Receptor Signaling 2Sts-2T-Cell Ubiquitin Ligand 1Tula-1 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ubiquitin-Associated And Sh3 Domain-Containing Protein A antibodyAnti-Cbl-Interacting Protein 4 antibodyAnti-Clip4 antibodyAnti-Suppressor Of T-Cell Receptor Signaling 2 antibodyAnti-Sts-2 antibodyAnti-T-Cell Ubiquitin Ligand 1 antibodyAnti-Tula-1 antibodyAnti-UBASH3A antibodyAnti-STS2 antibody |
Information sourced from Uniprot.org
