| Tissue Specificity | Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis. |
| Function | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. |
| Protein Name | Ubiquitin-Like Modifier-Activating Enzyme 6Ubiquitin-Activating Enzyme 6Monocyte Protein 4Mop-4Ubiquitin-Activating Enzyme E1-Like Protein 2E1-L2 |
| Database Links | Reactome: R-HSA-8866652Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-Ubiquitin-Like Modifier-Activating Enzyme 6 antibodyAnti-Ubiquitin-Activating Enzyme 6 antibodyAnti-Monocyte Protein 4 antibodyAnti-Mop-4 antibodyAnti-Ubiquitin-Activating Enzyme E1-Like Protein 2 antibodyAnti-E1-L2 antibodyAnti-UBA6 antibodyAnti-MOP4 antibodyAnti-UBE1L2 antibody |
Information sourced from Uniprot.org
