| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Nedd8-Activating Enzyme E1 Catalytic Subunit (1-463) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S4101RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UBA3 |
| Gene ID: |
9039 |
| Uniprot ID: |
UBA3_HUMAN |
| Immunogen Region: |
1-463 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-463 of human UBA3 (NP_003959.3). |
| Immunogen Sequence: |
MADGEEPEKKRRRIEELLAE KMAVDGGCGDTGDWEGRWNH VKKFLERSGPFTHPDFEPST ESLQFLLDTCKVLVIGAGGL GCELLKNLALSGFRQIHVID MDTIDVSNLNRQFLFRPKDI GRPKAEVAAEFLNDRVPNCN VVPHFNKIQDFNDTFYRQFH IIVCGLDSIIARRWINGMLI SLLNYEDGVLDPSSIVPLID GGTEGFKGNARVILPGMTAC IECTLELYPPQVNFPMCTI |
| Tissue Specificity | Ubiquitously expressed. |
| Function | Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. |
| Protein Name | Nedd8-Activating Enzyme E1 Catalytic SubunitNedd8-Activating Enzyme E1cUbiquitin-Activating Enzyme E1cUbiquitin-Like Modifier-Activating Enzyme 3Ubiquitin-Activating Enzyme 3 |
| Database Links | Reactome: R-HSA-5607761Reactome: R-HSA-5676590Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-Nedd8-Activating Enzyme E1 Catalytic Subunit antibodyAnti-Nedd8-Activating Enzyme E1c antibodyAnti-Ubiquitin-Activating Enzyme E1c antibodyAnti-Ubiquitin-Like Modifier-Activating Enzyme 3 antibodyAnti-Ubiquitin-Activating Enzyme 3 antibodyAnti-UBA3 antibodyAnti-UBE1C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
