| Tissue Specificity | Detected in erythrocytes (at protein level). Ubiquitous. |
| Post Translational Modifications | ISGylated. |
| Function | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. |
| Protein Name | Ubiquitin-Like Modifier-Activating Enzyme 1Protein A1s9Ubiquitin-Activating Enzyme E1 |
| Database Links | Reactome: R-HSA-8866652Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmMitochondrionNucleusIsoform 1: NucleusIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Ubiquitin-Like Modifier-Activating Enzyme 1 antibodyAnti-Protein A1s9 antibodyAnti-Ubiquitin-Activating Enzyme E1 antibodyAnti-UBA1 antibodyAnti-A1S9T antibodyAnti-UBE1 antibody |
Information sourced from Uniprot.org
